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Catholic University of Sacred Hearth - Rome

Laboratory of Antineoplastic Farmacology

A. Gemelli Polyclinic Largo Gemelli, 8 - 00168 Roma
Tel: 06-30151
web: www.ginecogemelli.it/ricerca/

Laboratory of Antineoplastic Pharmacology is sited in Catholic University of Sacred Hearth and is devoted to the development of novel strategies in the fight against cancer. Laboratory has two operative sites: one sited in the Dept. of Obstetrics and Gynaecology in "Policlinico Agostino Gemelli" in Rome, and a second in the Dept. of Oncology of "Centro di Ricerca e Formazione ad alta tecnologia nelle Scienze Biomediche" in Campobasso. Laboratoriy activities span from the high throughput screening of novel antitumor agents, to the validation phase and to toxicological studies performed in the experimental animal models. Laboratory is structured in two sections: 1. "In vitro" studies: this section is devoted to the high troughput screening of novel antitumor agents. 2. "In Vivo" studies: The Laboratory of in vivo pharmacology, is dealing with experimental models for studying new treatments in the field of anticancer and chemopreventive therapies. Examples of drug development recently occurred in the Laboratory are here following: the taxanes antitumor drug IDN5109 (now named as ortataxel and licensed to Bayer Corporation) has been screened and selected and is now undergoing worldwide phase II clinical trials for the treatment of chemoresistant lung and breast cancer; development process of IdB1016 (Indena S.p.A.) has been performed entirely in the Lab and is currently undergoing phase I/II clinical trial in the good clinical practice unit as novel agent for the treatment of ovaric carcinoma with serological recurrence (increase of tumor marker Ca125, without clinical evidence of disease relapse).


Scientific Coordinator
Prof. Giovanni, Scambia
Headquarters: via Banchi di Sotto, 55 - 53100 Siena ITALY
tel. +39 0577.234172 - +39 0577.234297 - fax. +39 0577.234333 - e-mail:info@natsyndrugs.com